All About AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
ATP is actually the most significant energy molecule present in the body. To make it simpler, this is the point where cellular function starts. Now because of the reason that energy is used by cells, ATP breaks down into ADP that actually has got less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. This is where AMPK steps in, it is sensing the relative ratios of ATP/ADP/AMP and telling the body if it needs more ADP so by that, it maintains proper functioning.
AMPK acts on various processes through different mechanisms. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. In the end, you are sure to reap plenty of benefits from improved AMPK activation like:
Anti aging – as we age, comes along with the gradual decline of AMPK activation. Experts actually think that AMPK is one of the contributing factors of aging. This promotes cellular renewal and at the same time, production of new mitochondria.
Anti inflammation – it is interesting to know that AMPK activation helps in decreasing inflammation but this too can be decreased by inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
Basically, there are more and more nutritional products and herbal products/constituents discovered that are very effective in AMPK activator to which some include:
Number 1. AICAR – this is AMP’s analog which is required for cellular use and storage similar to ATP. Since it’s the analog of AMP, AICAR can stimulate AMPK’s activity directly which can then improve muscle performance.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. This has been uncovered to have anti obesity effect and can increase insulin sensitivity.
Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.